Prof. Dr. V.R. RaviKKumar¹, Dr. Sanjesh Rathi² , Shubham Singh^3* , Dr. Bhoomi Patel⁴ , Sakshi Singh⁵, Kumkum Chaturvedi⁶  Bhawna Sharma⁷

¹Professor and Head, Dept. of Pharmacognosy, The Erode College of Pharmacy, Perundurai Main Road, Veppampalayam, Erode-638112, Tamilnadu, India

²Professor & Principal, School of Pharmacy, Rai University, Ahmedabad, Gujarat, India

³Assistant Professor, School of Pharmacy, Rai University, Ahmedabad, Gujarat, India

⁴Associate Professor, School of Pharmacy, Rai University, Ahmedabad, Gujarat, India

⁵United Institute of Technology, (UIT), Prayagraj, Uttar Pradesh, India

⁶Research Scholar, LNCT University, Kolar Road, Bhopal, M.P, India

⁷Assistant Professor, KDC College of Pharmacy, Mathura, Uttar Pradesh, India

* Address    for  Correspondence:

Mr. Shubham Singh (Assistant Professor)

School of Pharmacy, Rai University, Ahmedabad, Gujarat, India

Email: singhrbgj@gmail.com

Orcid ID. 0000-0002-5476-2882

Abstract

A peptic ulcer is a lesion (sore) on the stomach lining, or duodenum. Peptic ulcers are probably a twentieth-century condition. The ulcer disease continues to be a significant source of worldwide morbidity and mortality. The Gastrointestinal ulcers and duodenal ulcers are considered the two most extreme types of peptic ulcers. Peptic ulcers are found to be caused by an excess of violent factors including Hydrochloric acid (HCL) pepsin, refluxed bile leukotrienes (LT), reactive oxygen species (ROS) and protective factors, these include mucus-bicarbonate barrier functions, prostaglandins (PGs), mucosal blood flow, cell regeneration and migration, non-enzymatic and enzymatic and certain growth factors. The primary cause of peptic ulcer disease is pylori infection and the use of NSAIDs. This review article underscores the importance of a multidisciplinary approach in the management of ulcers to improve patient outcomes and quality of life.

Keywords  Peptic ulcer; Stomach; Sore; H.pylori; Infection

PDF A Comprehensive Review on Ulcer and Their Treatment.pdf