Biswajit Dash¹, Murshidha Shireen², Pushpendra^3*, Shivam Kumar⁴, Ankit Goel⁵, Preeti Semwal⁶, Rekha Rani⁷

¹Amity Institute of Pharmacy, Amity University-Kolkata, 700135, West Bengal, India

²Saveetha Institute of Medical and Technical Sciences, Chennai, 6022105, Tamil Naidu, India

³IFTM University, Lodhipur Rajput, Moradabad, 244102, Uttar Pradesh, India

⁴Yogendra Nath Saxena College of Pharmacy, Hasanpur, Uttar Pradesh, India

⁵Maharaja Agrasen Himalayan Garhwal University, Pauri Garhwal, 246169 Uttarakhand, India

⁶Siddhartha Institute of Pharmacy, Dehradun 248007, Uttarakahnd, India

⁷School of Pharmacy, ITM University, Gwalior, Madhya Pradesh, India

* Address    for  Correspondence:

Mr. Pushpendra

E-mail: pusp92744@gmail.com    

Orcid ID: 0000-0003-0078-9497

Abstract

Numerous factors, such as genetics, environmental factors, and illness determinants, might contribute to an unpleasant pharmaceutical response. In an effort to increase efficacy and safety, as well as to gain a better understanding of drug disposition and clinical consequences, researchers in the two quickly emerging fields of pharmacogenetics (which focuses on single genes) and pharmacogenomics (which focuses on many genes) have studied the genetic personalization of drug response. This is due to the fact that a large number of pharmacological responses seem to be genetically based, and the relationship between medication response and genotype may be important for diagnosis. We now have a better understanding of the genetic basis of individual medication responses because to research on pharmaceuticals and genes. Pharmacogenomics aims to improve patient outcomes by developing personalized medicine by using the diversity of the human genome and how it affects medication response. Translational in nature, pharmacogenomics research encompasses everything from the discovery of genotype-phenotype associations to clinical investigations that might show therapeutic relevance. Though the conversion of pharmacogenomics research findings into clinical practice has been sluggish, advances in the field offer considerable potential for future therapeutic applications in specific people.

Keywords  Pharmacogenomics, Genes, Pharmacogenetics, Medicine, Pharmacological

PDF A Comprehensive Review: Pharmacogenomics and Personalized Medicine Customizing Drug Therapy Based on Individual Genetics Profiles.pdf