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Development, Optimization and Evaluation of Mucoadhesive Microspheres of Amoxicillin for the Treatment of H.Pylori by Full Factorial Design
浏览量 396 时间 2024-07-24 09:22:21

Bhawna Sharma*, Dr. Anand Chaurasia, Dr. Naveen Gupta, Dr. Dharmendra Singh Rajput

Patel College of Pharmacy, Madhyanchal Professional University, Ratibad, Bhopal, MP. India


* Address    for  Correspondence:

Bhawna Sharma

Affiliation: Ph.D. Research Scholar, Patel College of Pharmacy, Madhyanchal Professional University, Ratibad, Bhopal, MP. India.

Email:  officialbhawna56@gmail.com 

ORCID ID:  https://orcid.org/0009-0009-8954-6328


Abstract

Objective: This work is aimed to formulate and evaluate Mucoadhesive Microspheres contain Amoxicillin for the effective use in the treatment of H.Pylori.

Methods: Microspheres were prepared using Emulsification-cross linking technique. To this guar gum (GG) and sodium alginate (SA) was dissolved in 200 ml of water and allowed to swell for 24 h at room temperature. And separately chitosan (CH) was dissolved in 2% (v/v) glacial acetic acid and this also kept for 24 h to swell or dissolve properly. After 24 h this swelled mixture was mixed under magnetic stirrer (Remi, India) at specific stirring rate for 1 h in order to find homogeneous mass of both the gum. Then slurry of chitosan also was homogenized for half an hour. The drug, Amoxicillin (1g) was then added to the chitosan solution and mixed homogeneously.

Results: The aim of the study was to formulate and evaluate microspheres, for SR of the chosen drug. The particle size of microspheres was in the range of 200-500 µ, maximum mucoadhesive property observed was 57.41% for Optimized formulation F-9, Drug release 68.52% till 8 h, and the maximum entrapment was 94.87% for F-9 formulation. The work also aims to study various parameters affecting the behavior of microspheres in oral dosage form.

Conclusion: Drugs with short half life that are absorbed from the gastrointestinal tract (GIT) are eliminated rapidly from the blood flow. To avoid this, the oral SR was developed as this formulation released the drug slowly into the GIT and maintained a stable drug concentration in the serum for a longer duration of time.


Keywords  Amoxicillin, Sodium alginate, Guar gum, Chitosan, Sustained release microspheres, In-vitro activity

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