Dr Puneet Sudan¹, Venkateswara Rao Jallepalli², Dr.B.Ramu³, Dr. Bhargav Bhongiri⁴, Dr S D Shanmuga Kumar⁵,

Dr. Meruva sathish kumar⁶, Dr V Ravi Kumar^7*

¹Professor ,Chandigarh Pharmacy College-Jhanjeri, Chandigarh Group of Colleges- Jhanjeri (Mohali) Punjab 140307, India

²Assistant Professor, Dept of Pharmacy Practice,MB School of Pharmaceutical Sciences, Mohan Babu University, Tirupati, India

³Professor,Depaertment of Pharmaceutics, K.V.K College of Pharmacy, Surmaiguda, Hyderabad, India

⁴Associate Director,Department of Pharmacology, Synpharma Research Lab, Dilsukhnagar,  Hyderabad, Telangana 500060, India

⁵Associate professor, Dept., Pharmaceutical Chemistry, Jyothismathi Institute of Pharmaceutical Sciences, Affliated to JNTUH, Thimmapur(M), Karimnagar, Telangana, 505527, India

⁶Associate Professor,M.N.R College of Pharmacy, MNR Higher Education and Research Academy Campus, Fasalwadi (V), Sangareddy, Telangana, 502294, India

⁷Professor,M.N.R College of Pharmacy, MNR Higher Education and Research Academy Campus, Fasalwadi (V), Sangareddy, Telangana, 502294, India

* Address    for  Correspondence:

Dr V Ravi Kumar

Professor, M.N.R College of Pharmacy

vemulapalli234@gmail.com

Abstract

Introduction: The traditional medicinal system of India, Ayurveda, has mentioned Cordia Dichotoma as a potential treatment for various ailments. In the current research, the extracts of Cordia Dichotoma was examined to evaluate their antidepressant potential.

Materials and methods: Here, green leaves of Cordia Dichotoma were used to prepare chloroform, ethanol, and aqueous extracts (referred to as CdCe, CdEe, and CdAe respectively). The research focused on investigating the antidepressant effects of these extracts using behavioral models in experimental animals. Additionally, locomotor activity was assessed as part of the evaluation process.

Results: Immobility time was reduced with CdEe Cordia Dichotoma rFST & mTST when at 200 mg/kg and 400 mg/kg body weight. The CdAe showed reduction in immobility time in the repeated rFST) at 400 mg/kg, while in the mTST, significant effects were observed at 200 and 400 mg/kg. Regarding the chloroform extract, it only exhibited a significant reduction in immobility time in the modified Tail Suspension Test (mTST) at a low dose of 200 mg/kg. However, no noticeable change in motor dysfunction was observed with CCl4 and aqueous extracts at doses of 200 and 400 mg/kg. It is worth noting that the chloroform extract (CdCe) did lead to a significant decrease in locomotor activity at the same dosage level. Taken together, these findings suggest that extracts obtained from Cordia Dichotoma leaves may possess antidepressant properties.

Keywords  Cordia Dichotoma; Antidepressant; motor dysfunction; Open field test; Flavonoids

PDF  Evaluation of Antidepresant Activity and Phytochemical Screening of Plant Cordia Dichotoma.pdf