Nandhini J¹, B. Anandhi², Soumya Stuti Patnaik³, Rahul Lotan Shirole⁴, Navinraj Dudhnath Mourya⁵, Nahida Siddiqui⁶,

Jithin Mathew⁷, V. R. Ravikkumar^8*, E. Karthikeyan⁹

¹Department of Pharmaceutics, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai - 602105, India

²The Erode College of Pharmacy, Erode, India

³Guru Nanak Institutions Technical Campus, India

⁴Department of Pharmacology, DCS’s A.R.A. College of Pharmacy, Nagaon, Dhule (MS) India

⁵School of Pharmacy, Rai University, Gujarat, India

⁶CMR College of Pharmacy, Kandlakoya, Hyderabad, Telangana, India

⁷Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Deralakatte, Paneer, Mangalore, Karnataka, India

⁸Dept. of Pharmacognosy, The Erode College of Pharmacy , Tamil Nadu Dr MGR Medical University Chennai, Perundurai Main Road, Veppampalayam, Erode-638112, Tamil Nadu, India

⁹Department of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai-602105, Tamilnadu, India

* Address    for  Correspondence:

Prof. Dr. V. R. Ravikkumar, 

Professor and Head, Dept. of Pharmacognosy, The Erode College of Pharmacy, Tamil Nadu Dr MGR Medical University Chennai, Perundurai Main Road, Veppampalayam, Erode-638112, Tamil Nadu, India

Orcid Id: 0000-0001-5549-8713

Abstract

The main issue with Hypertension therapy is quick commencement of effect. The creation of suitable dose forms may help address the issue of medications having a delayed beginning of effect. Oral Antihypertensive medication treatment is best suited for and has seen a rise in popularity with fast-disintegrating tablets. In terms of patient compliance, quick start of action, precise dosage, strong chemical stability, ease of self-administration, and compactness, they are superior to other traditional methods. As a popular hypertension medication, Propranolol HCl is a strong candidate for development into Fast Dissolving Tablets (FDTs). Because to first pass metabolism, it has a limited bioavailability. Therefore, the primary goal of the research was to create Propranolol HCl fast-dissolving tablets in order to increase the drug's bioavailability and dissolution rate. Microcrystalline cellulose used to make fast-dissolving Propranolol HCl tablets, together with varying concentrations of super disintegrates such as Chia Seed mucilage and sodium starch glycolate. Each batch was made by compressing it directly. Three formulation variables were combined, and the combined impact was examined using a 23 Full Factorial design. Here, the disintegration time is examined as a dependent parameter and the concentrations of chia seed mucilage, Sodium Starch Glycolate, and Microcrystalline Cellulose were considered as independent variables, X1, X2, and X3, respectively. The program Design Expert is used to depict the data.

Keywords  Salvia Hispanica, Mucilage, Fast dissolving tablets, Hypertension

PDF  Design and Development of Propranolol HCl Fast Dissolving Tablets by Using Isolated Mucilage of Salvia Hispanica for the Treatment of Hypertension by Using DoE tools.pdf