Parthasarathi Mishra^1*, Aswini Kumar Senapati¹, Sudhansu Ranjan Swain², Sujit Dash1, Suchismita Kar³

¹Institute of Pharmacy & Technology, Salipur, Cuttack, Odisha-754202, India

²Moradabad Educational Trust, Group of Institutions, Faculty of Pharmacy, Moradabad, U.P-244001, India

³Sri Jaydev College of Pharmaceutical Sciences, Naharkanta, Bhubaneswar, Odisha-752101, India

* Address    for  Correspondence:

Parthasarathi Mishra

Institute of Pharmacy & Technology, Salipur, Cuttack, Odisha-754202 India

Mail: parthasarathimshr@gmail.com, 

Mob: 9861644837

Abstract

The current study examined the antipsychotic properties of ethanolic extracts of Crinum asiaticum (EECA) and Crinum defixum (EECD). The effects of the extracts on rodents' ketamine-induced hyperactivity, amphetamine-induced stereotypy, forced swim test, conditioned avoidance response, and catalepsy were assessed. According to the findings, EECA and EECD both significantly outperformed typical antipsychotic medications in antipsychotic-like behaviours across a variety of behavioural paradigms. The extracts exhibited a 50-75% reduction in ketamine-induced hyperactivity, indicating a possible impact on glutamatergic signalling. Additionally, they greatly reduced amphetamine-induced stereotypy, suggesting a potential antagonistic interaction with the dopamine D2 receptor. Similar to haloperidol, EECD at 400 mg/kg dramatically decreased avoidance behaviour in the conditioned avoidance response test. Though less so than with haloperidol, both extracts caused catalepsy in rodents. The reversal of ketamine's effect in the forced swim test suggests that it may be effective in preventing psychosis's negative symptoms. Given that oxidative stress is a contributing factor to psychotic disorders, the antipsychotic effect of these extracts may be associated with their anti-inflammatory and antioxidant characteristics. These results bolster the long-standing usage of Crinum species in the treatment of mental illnesses and imply that they could be rich sources of new antipsychotic chemicals. To determine the active ingredients, clarify the mechanisms of action, and assess the safety and effectiveness of clinical trials, more study is necessary.

Keywords  Crinum asiaticum, Crinum defixum, Antipsychotic properties, Dopamine D2 receptor, Oxidative stress

PDF  Antipsychotic Activity of Ethanolic Extracts of Crinum asiaticum and Crinum defixum in Animal Models.pdf