SanjayKumar Patel^1*, Ismail.Y², Satendra Singh³, Sanjesh Rathi⁴, Shreya Shakya⁵, Sachin S. Patil⁶, Shrinivas Bumrela⁷, Priya Chhotulal Jain⁸, Priyanka Goswami⁹, Shubham Singh⁴

¹Sigmapharm laboratories llc, Bensalem, Pennsylvania, USA

²Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Chennai-600048, Tamilnadu, India

³GSVM Medical College (MBBS 3rd year Student), Kanpur-208002, Uttar Pradesh, India

⁴School of Pharmacy, Rai University, Ahmedabad, Gujarat, India

⁵Department of Pharmacology at Khyati College of Pharmacy, Gujarat Technological University (GTU), India

⁶DCS's ARA College of Pharmacy, Dhule, MS, India

⁷Latur College of Pharmacy,Latur Maharashtra, India

⁸A.R.A. College of Pharmacy, Mumbai-Agra Road, Nagaon, Dhule-424006, India

⁹Department of Pharmacognosy, Maharashtra Educational Society's, H.K. College of Pharmacy, Oshiwara, Jogeshwari (W), Mumbai : 400102, India

* Address    for  Correspondence:

SanjayKumar Patel

Sigmapharm laboratories llc, Bensalem, Pennsylvania, USA.

https://orcid.org/0009-0008-7834-9284

Abstract

There have been several non-invasive administrations that have emerged recently to replace conventional needle injections. With its minimal rejection rate, remarkable ease of administration, and remarkable patient comfort and perseverance, the transdermal drug delivery system (TDDS) is the most attractive of them all. The skincare industry, which includes cosmetics, may also find use for TDDS in addition to the pharmaceutical industry. As this strategy mainly entails local drug administration, it can prevent untargeted drug delivery to tissues not intended for the treatment and buildup of localized drug concentrations. Transdermal delivery is hampered by a number of physicochemical characteristics of the skin, which have led to a great deal of research into ways to get over these barriers. The majority of transdermal medicines that have proved effective do so by using smaller lipophilic compounds, which have a molecular weight of a few 100 Daltons. Transferosomes have proven to be an effective method for transdermal distribution of a range of therapies, including hydrophilic actives, bigger molecules, peptides, proteins, and nucleic acids, in order to get around the medications' size and lipophilicity limits. Because of their flexible form and increased surface hydrophilicity, transferosomes are essential for the delivery of medicines and other solutes through and into the skin by exploiting hydration gradients a source of energy. As a result, the medication is released into the skin layers under regulated conditions and has improved overall penetration. In this section we outline the development of transferosomes from liposomes and solid lipid nanoparticles, as well as their subsequent advancements as commercially available dosage forms, physical-chemical characteristics, and cutaneous kinetics.

Keywords  Transdermal Delivery, TDDS, Transferosomes, Nanoparticles, Stratum Corneum

PDF  Recent Innovations and Future Perspectives in Transferosomes for Transdermal Drug Delivery in Therapeutic and Pharmacological Applications.pdf