Ruchi Tiwari1, Anjali Paswan1, Gaurav Tiwari1, V. Jaya Sankar Reddy2*, Mahesh Kumar Posa3
1PSIT-Pranveer Singh Institute of Technology (Pharmacy), Kalpi Road, Bhauti, Kanpur-208020, India.
2Krishna Teja pharmacy college, Renigunta Road, Tirupati, Andhra Pradesh 517506, India
3School of Pharmaceutical Sciences, Jaipur National University, Jaipur-Agra Bypass, Near New RTO Office, Jagatpura, Jaipur-302017, India
* Address for Correspondence:
Dr. V. Jaya Sankar Reddy,
Vice principal,
Krishna Teja pharmacy college, Renigunta Road, Tirupati, Andhra Pradesh 517506, India
Email: shankarpharmacology@gmail.com
Abstract
Fecal microbiota Transplantation (FMT), often referred to as stool transplantation, fecal transfusion, and fecal bacteria therapy, is considered one of the most medical innovations of the 20th century. Fecal microbiota Transplantation entails filtering and dilution of a healthy donor's feces before injecting it into the recipient's digestive system. In China, it was first administered orally in the fourth century for diarrhea and food poisoning under the name "Yellow Soup." It has recently been widely employed in a variety of clinical settings, including cases of Clostridium difficile infection that are recurring and resistant. By replacing the unhealthy intestinal microbiota with a healthy bacterial community, the FMT treatment aims to enhance the intestinal flora. It also looks at neurological conditions where alterations in gut microbiota are prevalent. We have discussed FMT in the context of its use in conditions affecting the nerve system, such as neurological and other conditions (multiple sclerosis, Parkinson's disease, Alzheimer's disease, stroke, epilepsy, Amyotrophic lateral sclerosis, Tourette syndrome, neuropathic pain, Huntington's diseases, etc.), as well as the role of gut microbiota in many neurological disorders.
Keywords Gut-brain axis, Neurological Diseases, Applications of FMT, Delivery methods of FMT
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Perspectives on Fecal Microbiota Transplantation: Uses and Modes of Administration.pdf