Apexa M. Shah

Department of Pharmaceutics, Gandhinagar institute of Pharmacy, Gandhinagar University, India

* Address    for  Correspondence:

Apexa M. Shah

Department of Pharmaceutics, Gandhinagar institute of Pharmacy, Gandhinagar University, India

Email Id: apexa455@gmail.com

Tel: 9016405838

Abstract

Poorly soluble small compounds pose challenges in drug formulation due to low solubility, bioavailability, and therapeutic efficacy. These compounds often struggle to effectively target the disease due to their limited solubility. A large particle size further complicates reaching the desired site of action in the body. Reducing particle size through micronization or nanonization can enhance the efficacy of these active substances. Various methods, such as precipitation, milling, and high-pressure homogenization, are used to create nanocrystals, which can be delivered via multiple routes, with oral administration being preferred for safety and patient compliance. Nanonization is a key process in improving bioavailability, transforming micronized particles into nanoparticles under 1000 nm.

Keywords  Nanocrystal; Bottom-up; Top-down; Poor solubility; Bioavailability

PDF Advancements in Pharmaceutical Nanocrystals: A Comprehensive Review.pdf