Harsha Icharam Narkhede*, Karan Jayantilal Jain, Ishita Sanjay Dalvi, Umesh Bhagaji Gite

Department of Pharmaceutical Chemistry, SMBT College of Pharmacy, Dhamangaon, Nashik, Affiliated to Savitribai Phule Pune University, Pune, M.S. India-422403

* Address    for  Correspondence:

Dr. Harsha Icharam Narkhede

Department of Pharmaceutical Chemistry, SMBT College of Pharmacy, Affiliated to Savitribai Phule Pune University, Nandi-Hills, Dhamangaon, Tal-Igatpuri, Dist-Nashik, M.S., India-422403

Email: narkhede.harsha@gmail.com

Contact no. +91-9850683264

ORCID id: 0000-0002-3506-3592

Abstract

Autophagy, a highly conserved catabolic process, plays a fundamental role in maintaining cellular homeostasis by degrading and recycling unnecessary or dysfunctional cellular components through lysosomal pathways. It serves as a vital mechanism for clearing damaged proteins, organelles, and other cytoplasmic constituents, ensuring the cell's functional integrity, especially under stress conditions such as nutrient deprivation. Various forms of autophagy macro-autophagy, micro-autophagy, and chaperone-mediated autophagy are involved in distinct regulatory pathways that respond to different physiological and pathological stimuli. Recent research continues to uncover the molecular underpinnings and biological significance of these pathways, emphasizing their critical contributions to human health and disease.

Keywords  Autophagosome, Lysosome, mTOR Pathway, Phagophore, Protein Degradation

PDF  The Role of Autophagy in Maintaining Human Health and Disease Prevention.pdf